Little River is a census-designated place located in Horry County, South Carolina, within the Grand Strand region of the United States. Situated near the easternmost point of the state, it lies close to the border with North Carolina along the Atlantic Intracoastal waterway and the Waccamaw River. The community serves as a distinct residential and tourist zone, functioning initially as a suburb of North Myrtle Beach to provide easy access while avoiding that city's taxes.